Hallo,
also wenn man dem Datenblatt fürs 486 er Glauben schenken darf, dann sollten die beiden wohl pinkompatibel sein:
The EPSON CARD-486HB or CARD-486HBL can
be directly plugged into the existing products
which has been designed for the EPSON CARD-
386 or CARD-386L with some limitation.
Grüßle Bernd